omics.pnl.govIntegrative Omics | PNNL

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Their goal is to make the sample size as small as possible so that they can create maps or images of where proteins are located in tissue samples. Their latest demonstration achieved a lateral resolution of 100 um, or the width of the average human hair. Researchers eventually hope to map proteins in a tissue on a cell-by-cell basis. This technology is applicable across all fields of biology and so far researchers have applied it to studies of lung development, diabetes, Alzheimer’s disease, and tumor heterogeneity. Andrea Starr | Pacific Northwest National Laboratory Section Menu Chemical Biology Computational Biology Ecosystem Science Human Health Integrative Omics Advanced Metabolomics Chemical Biology Mass Spectrometry-Based Measurement Technologies Spatial and Single-Cell Proteomics Structural Biology Microbiome Science News & Updates Attend an Integrative Omics Event Publications Projects Explainer Articles Related Researchers Josh Adkins Laboratory Fellow, Biochemist, Group Leader Ron Moore Biosample Pipeline Team Lead, Mass Spectrometry Operations Lead Ernesto Nakayasu Biomedical Scientist Yehia Ibrahim Chemist, Instrument Development and Deployment Team Leader Thomas O. Metz Senior Scientist Tao Liu Senior Scientist Scott Baker Research Line Manager Mary Lipton Chemist Kristin E. Burnum-Johnson Science Group Leader for Functional and Systems Biology Paul Piehowski Chemist Life is dynamic, complex, and interconnected. At the foundation of those features are biomolecules—proteins, lipids, and metabolites that control the key steps in growing and maintaining life. Omics underpins much of PNNL’s biomedical and environmental scientific discovery and informs lab research into energy resilience and national security . Our integrative omics researchers unite analytical and computational technologies to dissect the molecular complexity of plants and people by employing mass spectrometry , bioinformatics, and computational biology. Omics-related projects at PNNL range from studying environmental microbiomes in soil and plant systems to characterizing biomolecules involved with cancer, diabetes, and chronic and infectious disease. All of this work benefits from collaborations with the Environmental Molecular Sciences Laboratory , a U.S. Department of Energy user facility located on the PNNL campus. Our environmental research uses omics to study bioenergy, carbon cycling,...